Search results for "oncogenic proteins"

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DOUBLE DEMONSTRATION OF ONCOGENIC HIGH RISK HUMAN PAPILLOMA VIRUS DNA AND HPV-E7 PROTEIN IN ORAL CANCERS

2011

Oncogenic HPVs are necessarily involved in cervical cancer but their role in oral carcinogenesis is debated. To detect HPV in oral cancer, 38 cases of formalin fixed-paraffin embedded OSCC were studied by both DNA genotyping (MY09/11 L1 consensus primers in combination with GP5-GP6 primer pair followed by sequencing) and immunohistochemistry (monoclonal Abs against capsid protein and HPV-E7 protein, K1H8 DAKO and clone 8C9 INVITROGEN, respectively). HPV-16 tonsil cancer was used as positive control. The overall prevalence of HPV infection in OSCCs was 10.5%. Amplification of DNA samples showed single HPV DNA infection in 3 cases (HPV16; HPV53; HPV70) and double infection in one case of chee…

AdultMaleHPVPapillomavirus E7 ProteinsImmunologyBiologymedicine.disease_causeVirusoral carcinogenesisSettore MED/28 - Malattie Odontostomatologicheoncogenic proteinsmedicineImmunology and AllergyHumansGenotypingPapillomaviridaeAgedNeoplasm StagingPharmacologyCervical cancerAged 80 and overE-7Papillomavirus InfectionsHPV infectionCancervirus diseasesMiddle Agedmedicine.diseaseHPV oral cancerVirologyfemale genital diseases and pregnancy complicationsstomatognathic diseasesCancer cellDNA ViralCarcinoma Squamous CellE-7; HPV; oncogenic proteins; oral carcinogenesis; OSCC;FemaleMouth NeoplasmsOSCCPrimer (molecular biology)Carcinogenesis
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